Sci. Pharm. 2011; 79: 351–358
Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery
Manas BHOWMIK * 1, Sanchita DAS 1, Dipankar CHATTOPADHYAY 2, Lakshmi K. GHOSH 1
1 Inorganic Pharmaceutics Research Lab II, Department of Pharmaceutical Technology, Jadavpur University, Kolkata- 700 032, India.
2 Department of Polymer Science & Technology, University College of Science & Technology, 92, A.P.C. Road, University of Calcutta, Kolkata-700 009, India.
* Corresponding author. E-mail: b_manasju@yahoo.co.in (M. Bhowmik)
Abstract
The aim of the present study was the development of thermo-sensitive in-situ gels for in-vitro evaluation of ophthalmic delivery systems of ketorolac tromethamine (KT), based on methylcellulose (MC) in combination with hydroxypropylmethyl cellulose (HPMC). The gel temperature of 1% MC solution was observed at 60°C. It was found that 6% oral rehydration salt without dextrose (ORS) was capable to reduce the gel temperature below physiological temperature. HPMC was added to increase viscosity and drug release time. The results indicated a large increase in viscosity at 37°C with addition of HPMC whch provided sustained release of the drug over a 4h period. From in-vitro release studies, it could be concluded that the developed systems were thus a better alternative to conventional eye drops.
Keywords
Methylcellulose • Hydroxypropylmethylcellulose • In-situ gel • ORS
Received October 14th, 2010 | Accepted March 1st, 2011 | Published Online March 5th, 2011
