Sci. Pharm. 2010; 78: 13–20
Different Spontaneous Pulmonary Metastasis Inhibitions against Lewis Lung Carcinoma in Mice by Bisdioxopiperazine Compounds of Different Treatment Schedules
Da-Yong LU * 1, Fu-Geng WU 2, Zu-Ming ZHEN 2, Ting-Ren LU 3, Hong-Ying WU 3, Jin-Yu CHE 1, Bin XU 2
1 Shanghai University, Shanghai 200444, PR China.
2 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
3 College of Sciences, Shanghai University, Shanghai 200444, PR China.
* Corresponding author. E-Mail: ludayong@sh163.net (D.-Y. Lu)
Abstract
Spontaneous neoplasm metastasis, a fatalist pathological feature of cancer, is a long-evolving, multi-steps process that can now only be treated or controlled by drugs or immuno-modulators. As we have previously hypothesized, each drug or immuno-modulator might act differently within various stages of a metastasis. Therefore any researches helping to determine these differences will be beneficial for updating therapeutics for metastasis. In this work, we have testified this hypothesis by using a series of well-known anti-metastatic agents – Bisdioxopiperazine compounds.
Keywords
Neoplasm metastasis • Bisdioxopiperazine compounds • Cancer chemotherapy • Probimane • Razoxane
Received October 25th, 2009 | Accepted December 28th, 2009 | Published Online December 29th, 2009
