Sci Pharm; 2009; 77: 805–815
Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney
Lili SEPEHR-ARA 1, Vahab BABAPOOR 2, Shahrbanoo ORYAN 3, Massoud MAHMOUDIAN * 4
1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 Department of physiology, Faculty of Veterinary medicine, Tehran University, Tehran, Iran.
3Department of Biology, Science Faculty, Teacher Training University, Tehran, Iran.
4 Razi Institute for drug Research, Iran University of Medical Sciences, Tehran, Iran.
* Corresponding author. E-mail: masmah99@iums.ac.ir (M. Mahmoudian)
Abstract
In previous researches mebudipine and dibudipine two newly synthesized calcium channel blockers (CCBs) showed considerable relaxant effects on vascular and atrial smooth muscle cells. In this study we investigated the effects of these new drugs on vascular flow of isolated rat kidney and compare their potencies to nifedipine. It is concluded that mebudipine and dibudipine (5 μM, 10 μM) caused concentration-dependent inhibition of increases in perfusion pressure induced by phenylephrine. Mebudipine (10 μM) inhibited more greatly increases in perfusion pressure induced by phenylephrine compared to (10 μM) nifedipine.
Keywords
Mebudipine • Dibudipine • Isolated rat kidney
Received June 24th, 2009 | Accepted August 26th, 2009 | Published Online August 27th, 2009
