Sci. Pharm. 2009; 77: 589–595
Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production
Phan M. GIANG * 1, Phan T. SON 1, Hui Z. JIN 2, Jeong H. LEE 2, Jung J. LEE 2
1 Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, 19 Le Thanh Tong Str., Hanoi, Vietnam.
2 Department Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea.
* Corresponding author. E-mail: firstname.lastname@example.org (P. M. Giang).
In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesqui-terpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells. The IC50 of these compounds were 1.97 μM ± 0.18 and 30.11 μM ± 4.10 in the NF-κB activation assay and 3.58 μM ± 0.46 and 34.7 μM ± 3.72 in the nitric oxide production assay, respectively.
Zerumbone • Zerumbone-2,3-epoxide • NF-κB • NO production
Received July 23rd, 2009 | Accepted August 6th, 2009 | Published Online August 6th, 2009