Sci Pharm; doi:10.3797/scipharm.0905-15 (retracted prior to print publication)

This article was retracted prior to print publication!
See the editorial in Sci. Pharm. 2010; 78: 118 (doi:10.3797/scipharm.ed-10-02)

Synthesis and In Vitro Antimycobacterial Activity of Trisubstituted s-Triazines

Jignesh P. RAVAL *, Anil J. MALAVIYA, Nilesh H. PATEL, Hemul V. PATEL, Pradip S. PATEL

Department of Pharmaceutical Chemistry, Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh vidyanagar – 388121Gujarat, India.

* Corresponding author. E-mails: drjpraval@yahoo.co.in or drjpraval@hotmail.com (J. P. Raval).

Abstract

A variety of 2-(N'-benzoylhydrazino)-4-(substitutedphenyl)amino-6-pyrazin-2-ylamino-1,3,5-triazines (7a–o) was synthesized from 2-aminopyrazine, isonicotinic acid hydrazide and cyanuric chloride. The structure of these compounds was confirmed by IR and NMR (¹H & ¹³C) spectral analysis and the newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among them, N'-{4-[(4-chlorophenyl)amino]-6-(pyrazin-2-ylamino)-1,3,5-triazin-2-yl}benzohydrazide (7g), N'-{4-[(4-methoxyphenyl)- amino]-6-(pyrazin-2-ylamino)-1,3,5-triazin-2-yl}benzo–hydrazide (7m) and 4-({4-[2-(phenylcarbonyl)hydrazino]-6-(pyrazin-2-ylamino)-1,3,5-triazin-2-yl}amino)- benzenesulfonamide (7o) showed the highest efficacy and exhibited >90% inhibition at a concentration of 0.0243 μM, 0.0266 μM and 0.0177 μM. The newly synthesized compounds were also evaluated for antimicrobial activity against a variety of bacterial strains and some of these compounds have shown significant antibacterial and antifungal activities as well.

Keywords

2-Aminopyrazine • Isonicotinic acid hydrazide • s-Triazine • Antimycobacterial activity • Mycobacterium tuberculosis H37Rv • Antibacterial activity • Antifungal activity

Received May 22^nd, 2009 | Accepted June 12^th, 2009 | Published Online June 13^th, 2009

This article was retracted prior to print publication!
See the editorial in Sci. Pharm. 2010; 78: 118 (doi:10.3797/scipharm.ed-10-02)

doi:10.3797/scipharm.0905-15