Sci. Pharm. 2009; 77: 389–399
NF-κB Inhibitory Activities of the Methanol Extracts and some Constituents therein of some Vietnamese Medicinal Plants
Nguyen H. NAM * 1, You Y. JAE 2
1 Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam.
2 Department of Chemistry, University of South Dakota, South Dakota, USA.
* Corresponding author. E-mail: nhnam@etal.uri.edu (N. H. Nam)
Abstract
Eighty-seven methanol extracts of medicinal plants, most of them are currently used in Vietnamese oriental medicine, were screened for NF-κB inhibitory activity. Seven methanol extracts showed strong to moderate inhibitory activity. These include the extracts of Crinum latifolium (leaves), Evodia rutaecarpa (fruits), Polygonum cuspidatum (rhizoma), Perilla ocymoides (leaves), Rubia cordifolia (leaves), Scutellaria barbata (leaves) and Sparganium stenophyllum (leaves). The NF-κB inhibitory activities of several metabolites isolated from some of these plants were also reported.
Keywords
NF-κB Inhibitory Activity • Screening • Medicinal Plants
Received March 26th, 2009 | Accepted May 12th, 2009 | Published Online May 14th, 2009
