Sci. Pharm. 2009; 77: 453–464
Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel
Afrouz YOUSEFI 1,2, Farnaz ESMAEILI 1,2, Sima RAHIMIAN 2, Fatemeh ATYABI 1, Rassoul DINARVAND * 1,3
1 Novel Drug Delivery Systems Lab., Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Iran.
2 Research and Development Dept., Sobhan Oncology Company, Rasht, Iran
3 Medical Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
* Corresponding author. E-mail: dinarvand@tums.ac.ir (R. Dinarvand).
Abstract
An improved pegylated liposomal formulation of docetaxel has been developed with the purpose of improving the docetaxel solubility without any need to use tween80 that is responsible for hypersensitivities following administration. Liposomes all had spherical shape with size of 130–160 nm. The most important finding of this study is that pegylated liposomes were prepared with significant increase in docetaxel encapsulation efficiency and stability of the formulation in comparison with last reports on docetaxel liposomes. In vitro release studies revealed that such a formulation could be stable in the blood circulation and meet the requirements for an effective drug delivery system.
Keywords
Docetaxel • Liposome • Stability • Pegylated • Nanoparticle
Received June 9th, 2008 | Accepted March 18th, 2009 | Published Online March 19th, 2009
