Sci. Pharm. 2009; 77: 355–366
The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities
Rafat M. MOHAREB * 1,2, Elham Ezz EL-ARAB 3, Karam A. EL-SHARKAWY 1
1 Faculty of pharmacy, October University for Modern Sciences & Arts, Elwahaat Road, October City, A. R. Egypt.
2 Faulty of Science, Chemistry Department, Cairo University, A. R. Egypt
3 National Organization of Drug Control & Research (NODCAR), P.O. 29, Cairo, A. R. Egypt
* Corresponding author. E-Mail: raafat_mohareb@yahoo.com (R. M. Mohareb).
Abstract
The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2–10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs.
Keywords
Pyridine • Thiophene • Thiazole • Antimicrobial
Received January 18th, 2009 | Accepted March 11th, 2009 | Published Online March 14th, 2009
