Sci. Pharm. 2009; 77: 309–326
Mouth Dissolving Tablets I: An Overview of Formulation Technology
Dali SHUKLA, Subhashis CHAKRABORTY, Sanjay SINGH, Brahmeshwar MISHRA *
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India.
* Corresponding author. E-mail: bmishrabhu@rediffmail.com (B. Mishra)
Abstract
Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. MDDDS have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Therefore, these dosage forms have lured the market for a certain section of the patient population which include dysphagic, bed ridden, psychic, geriatric and paediatric patients. Several techniques have been developed in the recent past, to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This article focuses on the technologies available and the advances made so far in the field of fabrication of mouth dissolving tablets. Apart from the conventional methods of fabrication, this review also provides the detailed concept of some unique patented technologies like Zydis, Lyoc, Quicksolv, Orasolv, Durasolv, Flashtab, Oraquick, Wowtab and Ziplet alongwith their advantages and limitations.
Keywords
Mouth dissolving • Fast disintegrating • Dysphagia • Lyophilization • Direct compression
Received November 6th, 2008 | Accepted March 5th, 2009 | Published Online March 6th, 2009
