Sci Pharm. 2008; 76: 567–598.
Cyclodextrins as Drug Carrier Molecule: A Review
ARUN RASHEED *, ASHOK KUMAR C. K., SRAVANTHI V. V. N. S. S.
Department of Pharmaceutical Chemistry, Sree Vidyanikethan College of Pharmacy, Sri Sainath Nagar, Tirupati, Andhra Pradesh, India-517502
* Corresponding author. E-mail: arunrasheed@rediffmail.com (R. Arun).
Abstract
The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical application of cyclodextrin is to enhance the solubility, stability, safety and bioavailability of drug molecules. The purpose of this review is to discuss and summarize some of the findings and applications of cyclodextrin (CD) and their derivatives in different areas of drug delivery. This article highlights the molecular structure, properties like complexation, solubility etc. of cyclodextrins and focuses on its use for parenteral, oral, ophthalmic and nasal drug delivery. Other routes including dermal, rectal, sublingual and pulmonary delivery are also briefly addressed. The objective of this contribution is to focus on the potential use of chemically modified cyclodextrins as high-performance drug carriers in drug delivery systems with emphasis on the more recent developments. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems associated with the delivery of different novel drugs through different delivery routes.
Keywords
Cyclodextrins • Drug formulation • Drug delivery • Complexation • Novel delivery systems
Received August 5th, 2008 | Accepted October 31st, 2008 | Published Online November 1st, 2008
