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Sci. Pharm. 2011; 79: 623–634

Type 2 Diabetes Mellitus-Induced Hyperglycemia in Patients with NAFLD and Normal LFTs: Relationship to Lipid Profile, Oxidative Stress and Pro-Inflammatory Cytokines

Mohamed E. E. SHAMS * 1, Mohammed M. H. AL-GAYYAR 2–4, Enaase A. M. E. BARAKAT 5

1 Department of Pharmaceutics, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
2 Department of Biochemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
3 Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, USA.
4 Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
5 Department of Internal Medicine, Faculty of Medicine, University of Mansoura, Mansoura, Egypt.

* Corresponding author. E-mail: mshamspharma@gmail.com (M. E. E. Shams)

Abstract

Type 2 diabetes mellitus is associated with dyslipdemia, insulin resistance and non alcoholic fatty liver disease. The purpose of the current study was to assess whether type 2 diabetes mellitus-induced hyperglycemia has an effect on the lipid profile and release of oxidative stress markers and inflammatory mediators in patients with non alcoholic fatty liver disease and normal liver function tests which may in turn lead to enhancing the pathogenicity of this liver disease. For this purpose, one hundred and five outpatients, matched in age and weight, were classified into two groups: the first group consisted of patients with non alcoholic fatty liver disease and the second group consisted of patients with non alcoholic fatty liver disease in conjunction with hyperglycemia due to the presence of type 2 diabetes mellitus. In all patients, lipid profile, oxidative stress, and inflammatory mediators were assessed by measuring serum concentrations of triglycerides, low density lipoprotein, hydrogen preroxide, malondialdehyde, tumor necrosis factor-alpha and interleukin-6, respectively. In the studied population, it was found that the presence of type 2 diabetes mellitus-induced hyperglycemia significantly impaired lipid profile, and significantly enhanced the formation of hydrogen preroxide and malondialdehyde as well as significantly increased the release of tumor necrosis factor-alpha and interleukin-6 in the second group of patients. In addition, plasma glucose level showed significant positive correlation with hydrogen peroxide, malondialdehyde, tumor necrosis factor-alpha and interleukin-6. From the previous results, it was concluded that the presence of type 2 diabetes mellitus-induced hyperglycemia results in significant increase in lipid profile, oxidative stress markers and inflammatory mediators in patients with non alcoholic fatty liver disease and normal liver function tests. For this reason, further research studies may be essential to evaluate the benefit of adding suitable antioxidant and anti-inflammatory drugs to the treatment regimen for this group of patients. In addition, regular monitoring of blood glucose levels and liver function tests should be advised to this category of patients to reduce liver fat deposition and avoid the development of non alcoholic steatohepatitis, cirrhosis or liver cancer and their related complications. Keywords

Keywords

Nonalcoholic Fatty Liver Disease (NAFLD) • Type 2 diabetes • Obesity • Lipid profile • Oxidative stress • Antioxidants • TNF-α • IL-6

Received April 25th, 2011 | Accepted May 29th, 2011 | Published Online May 26th, 2011

doi:10.3797/scipharm.1104-21